Paola Leone Selected Research

aspartoacylase

12/2016	N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
12/2012	Long-term follow-up after gene therapy for canavan disease.
1/2009	Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat.
7/2006	Novel role for aspartoacylase in regulation of BDNF and timing of postnatal oligodendrogenesis.
1/2006	Mutation analysis of the aspartoacylase gene in non-Jewish patients with Canavan disease.
7/2002	Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain.

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Paola Leone Research Topics

Disease

10	Canavan Disease (Leukodystrophy, Spongiform) 12/2016 - 07/2002
4	Neuroinflammatory Diseases 05/2022 - 01/2019
4	Inflammation (Inflammations) 08/2021 - 01/2019
4	Disease Progression 01/2021 - 12/2012
3	Ataxia (Dyssynergia) 08/2021 - 09/2007
2	Cognitive Dysfunction 05/2022 - 11/2019
2	COVID-19 01/2021 - 10/2020
2	Infections 01/2021 - 10/2020
2	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 01/2013 - 01/2012
2	Tremor (Tremors) 01/2009 - 07/2006
1	Non-alcoholic Fatty Liver Disease 05/2022
1	Fatty Liver 08/2021
1	Delirium 01/2021
1	Hyperammonemia 01/2020
1	Autism Spectrum Disorder 01/2020
1	Erectile Dysfunction 11/2019
1	Hepatic Encephalopathy 01/2019
1	Liver Diseases (Liver Disease) 01/2019
1	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Alzheimer Disease (Alzheimer's Disease) 03/2015
1	Neoplasms (Cancer) 07/2014
1	Mucopolysaccharidosis I (Hurler Syndrome) 01/2014
1	Gliosis 01/2013
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 03/2008
1	Pneumonia (Pneumonitis) 10/2007
1	Bronchopulmonary Dysplasia 10/2007
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 09/2007
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 11/2005
1	Intellectual Disability (Idiocy) 10/2005
1	Bipolar Disorder (Manic Depressive Psychosis) 10/2005
1	Hyperglycemia 03/2002
1	Hypoglycemia (Reactive Hypoglycemia) 03/2002
1	Drug Resistant Epilepsy 03/2002

Drug/Important Bio-Agent (IBA)

8	EnzymesIBA 12/2016 - 07/2002
6	aspartoacylaseIBA 12/2016 - 07/2002
6	N-acetylaspartate (N-acetyl aspartate)IBA 12/2016 - 10/2005
3	Rifaximin (L 105)FDA Link 05/2022 - 01/2019
3	Biomarkers (Surrogate Marker)IBA 01/2013 - 10/2005
2	N-Methylaspartate (NMDA)IBA 05/2022 - 01/2019
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2021 - 10/2020
2	SARS-CoV-2 spike proteinIBA 01/2021 - 10/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2020
2	LectinsIBA 01/2021 - 10/2020
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2016 - 01/2009
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2013 - 03/2002
2	Sulfoglycosphingolipids (Sulfatides)IBA 01/2013 - 01/2009
2	lithium citrate FDA LinkGeneric 07/2010 - 10/2005
2	LithiumIBA 07/2010 - 10/2005
2	Buspirone (Buspar)FDA LinkGeneric 05/2008 - 09/2007
1	Glutamic Acid (Glutamate)FDA Link 05/2022
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 05/2022
1	BenzodiazepinesIBA 01/2021
1	Hypnotics and Sedatives (Sedatives)IBA 01/2021
1	AmmoniaIBA 01/2020
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Interleukin-6 (Interleukin 6)IBA 01/2020
1	Dinoprostone (PGE2)FDA Link 01/2020
1	Tadalafil (Cialis)FDA Link 11/2019
1	Sildenafil Citrate (Viagra)FDA Link 01/2019
1	PregnenoloneIBA 01/2019
1	CytokinesIBA 01/2019
1	AMPA Receptors (AMPA Receptor)IBA 01/2019
1	gamma-Aminobutyric Acid (GABA)IBA 01/2019
1	BicucullineIBA 01/2019
1	sulforaphaneIBA 01/2019
1	Ibuprofen (Motrin)FDA LinkGeneric 01/2019
1	GABA Plasma Membrane Transport ProteinsIBA 01/2019
1	Eosine Yellowish-(YS) (Eosin)IBA 01/2018
1	Hematoxylin (Haematoxylon)IBA 01/2018
1	GATA6 Transcription FactorIBA 07/2014
1	triheptanoinIBA 05/2014
1	Iduronidase (alpha-L-Iduronidase)IBA 01/2014
1	SphingolipidsIBA 01/2013
1	Inositol (Myoinositol)IBA 01/2013
1	Warfarin (Coumadin)FDA LinkGeneric 01/2012
1	Vitamin K FDA Link 01/2012
1	CerebrosidesIBA 01/2009
1	LipidsIBA 01/2009
1	Hexosaminidase A (Hex A)IBA 03/2008
1	NF-kappa B (NF-kB)IBA 10/2007
1	SteroidsIBA 10/2007
1	Serotonin ReceptorsIBA 09/2007
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 07/2006
1	PyrimidinesIBA 11/2005
1	PurinesIBA 11/2005
1	N-acetylglutamic acidIBA 11/2005
1	isospaglumic acid (NAAGA)IBA 11/2005
1	Dicarboxylic AcidsIBA 11/2005
1	Amino Acids FDA Link 11/2005
1	Glucose (Dextrose)FDA LinkGeneric 03/2002

Therapy/Procedure

4	Therapeutics 05/2022 - 10/2005
1	Early Ambulation 01/2021
1	Transcranial Magnetic Stimulation 01/2020
1	Palliative Care (Palliative Therapy) 01/2012